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Antibiotic Prophylaxis

Preop Administration Time and Intra-op Dosing of Antibiotic Prophylaxis


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Prophylaxis for Pancreatoduodenectomy (Whipple)
  • 4.5g Piperacillin (4g) / Tazobactam (0.5g) (Pip/Tazo) IV pre-incision, then q4hours intraop redose.
  • For patients with renal insufficiency (CrCl < 30ml/min), adjust Pip/Tazo dose to 3.375g.
  • Vials of Pip/Tazo can be obtained from Pyxis MedStation.
  • Piperacillin-Tazobactam Compared With Cefoxitin as Antimicrobial Prophylaxis for Pancreatoduodenectomy. A Randomized Clinical Trial. JAMA. 2023;329(18):1579-1588

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